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KMID : 0381120130350060741
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Genes and Genomics
2013 Volume.35 No. 6 p.741 ~ p.746
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Ligularia fischeri regulates lung cancer cell proliferation and migration through down-regulation of epidermal growth factor receptor and integrin β1 expression
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Cho Young-Rak
Kim Jin-Kyu
Kim Jae-Hyeon
Oh Joa-Sub
Seo Dong-Wan
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Abstract
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In the present study, we report the effect and molecular mechanism of Ligularia fischeri (LF) on proliferation and migration in human lung cancer cells. LF-mediated inhibition of cell proliferation in p53 wild-type A549 and p53-deficient H1299 cells is accompanied by reduced expression of cell cycle-related proteins such as cyclin-dependent kinases and cyclins, resulting in pRb hypophosphorylation and G1 phase cell cycle arrest. In contrast, LF inhibits cell migration in A549 cells, but not in H1299 cells. These regulatory effects of LF on cell proliferation and migration are associated with inactivation of mitogenic signaling pathways such as ERK, Akt and p70S6K, and down-regulation of epidermal growth factor receptor and integrin β1 expression. Collectively, these findings suggest further development and evaluation of LF for the prevention and treatment of lung cancer with mutated p53 as well as wild-type p53.
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KEYWORD
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Ligularia fischeri, Epidermal growth factor receptor, Integrin β1, Lung cancer, P53
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